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Feasibility of breath-hold techniques in irradiation of pancreatic cancer, a pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON25458

Enrollment

Registered

2013-12-15

Start date

2014-03-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Resectable pancreatic cancer, borderline resectable pancreatic cancer, irresectable pancreatic cancer, radiochemotherapy, breath hold technique for radiation, fiducial markers

Interventions

No additional therapeutic interventions During preparatory CT and once weekly during fractionated radiation, additional imaging shall be performed in breath hold conditions.

Eligibility

Inclusion criteria

Inclusion criteria: - Patients with pancreatic cancer, locally advanced or (borderline) resectable status, who are treated with radio(chemo)therapy; - WHO performance status of 0-2; - Written informed consent.

Exclusion criteria

Exclusion criteria: - Inability to undergo the additional treatment planning CT scan and fluoroscopy; - Serious lung condition precluding breath-hold

Design outcomes

Primary

Measure	Time frame
Comparison of preparatory, inter and intra fraction tumour motion between free breathing and breath hold conditions	—

Secondary

Measure	Time frame
- Feasibility of irradiation in breath hold conditions - Calculation of change in margins in breath hold conditions compared to free breathing - Calculation of potentially resulting changes in normal tissue complication probability (NTCP)	—

Contacts

Public ContactG. Tienhoven, van

Academic Medical Center Department of radiation oncology Meibergdreef 9

g.vantienhoven@amc.uva.nl+31 (0)20 5665591

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)