Osteoarthritis, Knee
Conditions
Interventions
Knee Joint Distraction is performed according to the methodology as used in previous knee distraction studies, using 2 monotubes, one laterally and one medially. Intra-operative the tubes are distract
Sponsors
University Medical Center Utrecht (UMCU)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with medial or lateral tibio-femoral compartmental OA considered for HTO according to regular clinical practice; 2. Age < 65 years; 3. Radiological joint damage: Kellgren & Lawrence score above 2; 4. Intact knee ligaments; 5. Normal range-of-motion (min. of 120° flexion); 6. Normal stability; 7. Body Mass Index < 35.
Exclusion criteria
Exclusion criteria: 1. Mechanic axis-deviation (varus-valgus) of less than 10 degrees; 2. Psychological inabilities or difficult to instruct; 3. Not able to undergo MRI examination (standard daily clinical practice protocol); 4. Inflammatory or rheumatoid arthritis present or in history; 5. Post traumatic fibrosis due to fracture of the tibial plateau; 6. Bone-to-bone contact in the joint (absence of any joint space on X-ray); 7. Surgical treatment of the involved knee < 6 months ago; 8. Contra-lateral knee OA that needs treatment; 9. Primary patello-femoral OA.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cartilage changes determined by decrease in denuded bone areas using quantitative MRI analyses. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cartilage changes determined by X-rays, additional quantitative MRI parameters and biomarker analyses; 2. Clinical effectiveness determined by KOOS questionnaire; 3. Pain evaluated with VAS score; 4. Indication of cost-effectiveness. | — |
Contacts
Public ContactK. Wiegant
Heidelberglaan 100
Outcome results
None listed