Perioperatieve veranderingen in de microvasculaire perfusie in patiënten die coronaire bypass chirurgie ondergaan.

Perioperative changes in the microvascular perfused boundary region in patients undergoing coronary artery bypass grafting.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON25389

Enrollment

Registered

2013-10-17

Start date

2013-11-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac surgery, Coronary Artery Bypass Grafting (CABG), Cardiopulmonary Bypass (CPB), microcirculation

Interventions

The endothelial glycocalyx (EGC) is a gel-like layer that acts as a natural coating for endothelial cells, thereby preventing these cells from having direct contact with circulating blood cells. In or

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patients undergoing CABG surgery (18-85 years); 2. Informed consent

Exclusion criteria

Exclusion criteria: 1. Re-operations; 2. Emergency operation; 3. Patients with diabetes mellitus; 4. Patients with a history of hematologic disorders or hepatic disease or renal replacement therapy; 5. Patients with a body mass index (BMI) above 35 kg/m2.

Design outcomes

Primary

Measure	Time frame
Perioperative changes in the perfused boundary region of the sublingual microvasculature.	—

Secondary

Measure	Time frame
Shedding of Syndecan-1, heparan sulphate and hyaluronic acid.	—

Contacts

Public ContactA.B.A. Vonk

Dept. of Cardio-thoracic surgery VU University Medical Center De Boelelaan 1117

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)