Characterising the histopathology of immunotherapy-induced colitis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON25386

Enrollment

100

Registered

2019-11-04

Start date

2018-02-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICI therapy-induced colitis, untreated Crohn’s colitis, untreated Ulcerative colitis, or GvH-colitis following allogenic stem cell transplantation

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: - Diagnosis of ICI therapy-induced colitis, Crohn’s colitis, Ulcerative colitis, or GvH-colitis following allogenic stem cell transplantation confirmed by histopathological analysis.

Exclusion criteria

Exclusion criteria: - Previous treatment of Crohn’s colitis and Ulcerative colitis

Design outcomes

Primary

Measure	Time frame
Numbers and distribution of CD4+ T cells, CD8+ T cells, and CD68+ macrophages in different hotspots. Variation between hotspots per patients	—

Contacts

Public ContactJacco de Haan

University Medical Center Groningen

j.j.de.haan@umcg.nl050-361281

Outcome results