rheumatoid arthritis, undifferentiated oligo- or polyarthritis
Conditions
Interventions
Methotrexate, in case of insufficient response followed by adalimumab, and then by a combination of methotrexate, sulfasalazine, hydroxychloroquin and prednisone versus usual care according to prefere
Sponsors
Prof dr BAC Dijkmans
VUmc
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18+; 2. Symptom duration less than 3 years; 3. Swelling 2-5 joints.
Exclusion criteria
Exclusion criteria: 1. Earlier treatment with disease modifying antirheumatic drugs except hydrxychloroquine; 2. Prednisone use within 3 months; 3. Bacterial arthritis, crystal induced arthritis, reactive arthritis, sarcoidosis, osteoarthritis or systemic autoimmune disease other than RA; 4. Pregnancy; 5. Erosive disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression of radiographic damage score after 2 years. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Functional capacity; 2. Quality of life; 3. Disease activity. | — |
Contacts
Public ContactD. Schaardenburg, van
Jan van Breemen Institute, Dr. Jan van Breemenstraat 2
Outcome results
None listed