Periampullary cancer / Pancreatoduodenectomy
Conditions
Interventions
None listed
Sponsors
Cancer Center Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1) Age > 18 years 2) Written informed consent 3) Understanding of the Dutch language 4) Willing and capable of following instructions for this study 5) Patients need to be able to achieve a minimal daily dietary fat intake of > 60 grams
Exclusion criteria
Exclusion criteria: 1) Any known gastrointestinal disease or major gastrointestinal surgery (apart from a PD) that could potentially affect the intestinal absorption or metabolism of fat 2) Gastroparesis of any aetiology 3) Serious concomitant systemic disorders that would compromise the safety of the patient or his/her ability to complete the study, at the discretion of the treating physician 4) Patients who are unable to cease anti-diarrheal medication or laxatives 5) Patients who are suspected not to be reliable in participating in this study, based on the physician’s experience
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint of this study is diagnostic accuracy of various diagnostic tests such as the FET, the 13C-MTG breath test and the 24-hour faecal fat quantification, Sudan stain test compared to the 72-hour faecal fat quantification to detect EPI in patients with a newly diagnosed periampullary cancer and after a PD. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Incidence of EPI at time of diagnosis of periampullary cancer and after a PD 2) Course of exocrine pancreatic function after a PD 3) Presence of micronutrient deficiencies 4) To evaluate whether the occurrence of EPI can be predicted based on the development of specific signs or symptoms | — |
Contacts
Public ContactLotte Blonk
Amsterdam UMC, location VUmc
Outcome results
None listed