patients' preference, transplant patients, actinic keratosis, imiquimod, 5-Fluorouracil, Photodynamic therapy.
Conditions
Interventions
Left/right MAL-PDT and left/right respectively topical treatment.
Sponsors
Erasmus MC, department dermatology
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adults (above the age of 18 years old); 2. Solid organ transplant recipients (heart, lung, kidney and liver) under stable immunosuppressive treatment since 6 months; 3. Informed consent signed; 4. More than 5 mild to moderate AK (clinical diagnosis) on both dorsal hands with symmetrical involvement in term of severity and number.
Exclusion criteria
Exclusion criteria: 1. A treatment for AK on the dorsal hand in the last 3 months; 2. Taking oral retinoid within 4 weeks before enrolment; 3. Pregnancy or breastfeeding during the study; 4. A proven allergy for one of the used products in the study; 5. Other skin disease including invasive SCC on the dorsa of the hand; in doubt histology will be performed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patients preference. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cosmetic outcome; 2. Tolerability; 3. Efficacy. | — |
Contacts
Public ContactH.A.M. Neumann
Department of Dermatology Erasmus MC
Outcome results
None listed