1. Colorectal cancer
Conditions
Interventions
1. Sigmoidoscopy
2. Guaiac fecal occult bloed test
3. Immunochemical fecal occult bloed test.
Sponsors
Initiator: Erasmus MC, University Medical Center Rotterdam
Department of Gastroenterology and hepatology
Eligibility
Inclusion criteria
Inclusion criteria: 1. 50-75 year old; 2. Ability to provide informed consent.
Exclusion criteria
Exclusion criteria: 1. Inability or refusal to provide informed consent; 2. History of colorectal cancer, adenomas, inflammatory bowel disease*; 3. Severe or terminal disease, life expectancy less than five years; 4. Colonoscopy, sigmoidoscopy or contrast barium enema within the previous three years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Attendance for CRC screening with guaiac based FOBT (Haemoccult II), immunochemical FOBT (OC-Hemodia Latex) and sigmoidoscopy. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The diagnostic yield of FOBT screening and sigmoidoscopy based screening in the Netherlands; 2. The feasibility and required capacity for primary sigmoidoscopy CRC screening in our country; 3. The feasibility and required colonoscopy capacity needed for further evaluation of participants with a positive screening test in relation to the initial screening method used; 4. Side effects of screening; 5. Participants experiences; the acceptability, satisfaction and burden of screening (FOBT or sigmoidoscopy); 6. Identification of optimal choices for implementation of a CRC screening program (process evaluation); 7. Comparison of the cost-effectiveness ratio of the two forms of FOBT and sigmoidoscopy in CRC screening. | — |
Contacts
Public ContactL. Hol
Erasmus MC, University Medical Center Rotterdam ’s-Gravendijkwal 230 Department of Gastroenterology and hepatology
Outcome results
None listed