If the protein oxidation breath test has discriminative powers, the breath test could be applied as a screening tool in people who are of risk at having malnutrition. Currently, the breath test will be tested on healthy volunteers.
Conditions
Interventions
4 days of high protein diet (1,35 g protein / kg bodyweight /day) at habitual energy intake followed on day 5 by the protein oxidation breath test.
4 days of medium protein diet (0,8 g protein / kg b
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: Healthy volunteers: Male Age between 18 - 30
Exclusion criteria
Exclusion criteria: - Disease and/or being medically treated (e.g. diabetes mellitus) - Milk (protein) allergy or intolerance - Smoking - Drug use - Alcoholism, and no alcohol during the 4-day diets - Waist circumference ≥102 cm - Vegetarian
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total 13C-protein oxidation measured by the breath test over 5,5 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| 4-day food diaries. 1 for baseline measurement of habitual energy and protein intake. The other three for the different interventions. 24-hour urine collection for measuring urea (protein intake) and creatinine (muscle mass) | — |
Contacts
Public ContactGerlof Reckman
Hanzeplein 1 UMCG
Outcome results
None listed