Take Control!

Take Control! - Targeting Cocaine Dependence by Targeting Underlying Cognitive Processes

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON25286

Enrollment

100

Registered

2014-03-06

Start date

2014-03-15

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cocaine dependence, cocaine afhankelijkheid addiction, verslaving

Interventions

- 25 days working memory or placebo training - 25 days 2400 mg/d N-Acetylcysteine capsules or placebo capsules This results in 4 groups: (1) working memory training and N-acetylcysteine, (2) working

Eligibility

Inclusion criteria

Inclusion criteria: 1. males 2. 18 -60 years old 3. minimal 2 DSM-5 critieria AND using cocaine at least 4 times per month

Exclusion criteria

Exclusion criteria: 1. Major illnesses; 2. Two or more DSM-5 substance use disorder criteria for heroin 3. Ulcers; 4. MRI incompatibility

Design outcomes

Primary

Measure	Time frame
- cocaine use -glutamatergic concentrations in the dorsal ACC and rostral ACC - working memory improvement - craving	—

Secondary

Measure	Time frame
- cue reactivity	—

Contacts

Public ContactMieke Mors-Schulte, ter

Academic Medical Center University of Amsterdam Department of Psychiatry PA3-225 P.O. box 22660

m.termors.schulte@gmail.com+31 (0)20 8913704

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)