Patients with DM II.
Conditions
Interventions
1. Treatment with pioglitazone 30 mg once a day or placebo
2. Infusion of a lipid emulsion on the third study day in the active treatment group.
Sponsors
Eli Lilly
Eligibility
Inclusion criteria
Inclusion criteria: 1. Obese patients with Diabetes Mellitus type II (DM II); 2. BMI > 25 kg/m2; 3. Treatment for DM II with oral medication only; 4. Moderatly regulated DM II.
Exclusion criteria
Exclusion criteria: 1. Use of insulin; 2. Use of fibrates; 3. Plasma creatinine > 150 umol/L; 4. Transaminases > 2x upper limit of reference value; 5. Impaired cardiac function or angina pectoris; 6. Familial lipid metabolism disorder; 7. Women in reproductive age; 8. Epilepsy; 9. Proliferative retinopathy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Basal glucose production and plasma FFA peripheral insulin sensitivity insulin-mediated suppression of FFA (=insulin sensitivity of adipose tissue). | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in concentrations of ceramide and glycosphingolipids in skeletal muscle. | — |
Contacts
Public ContactM.J.M. Serlie
Academic Medical Center (AMC), Department of Endocrinology and Metabolism (F5-169) P.O. Box 22660
Outcome results
None listed