non-metastasized esophageal cancer
Conditions
Interventions
adding capecitabine to the standard radiation schedule
Sponsors
amsterdamumc
Eligibility
Inclusion criteria
Inclusion criteria: - Age of 18 years or older - WHO performance score 0-3 - Biopsy proven carcinoma of the esophagus - cT1-T4aN0-3M0, including patients with M1 disease based on pathologic nodes at supraclavicular or truncus coeliacus level - The multidisciplinary team rejects surgical treatment - The radiation oncologist and medical oncologist consider patient not eligible for the standard chemoradiation, with at least one of the following characteristics: WHO performance 3, age of > 80 year, metabolic disorders excluding Carboplatin or Paclitaxel, mainly wheelchair bounded, evidence of interstitial lung disease or active, non-infectious pneumonitis, or a Charlson index of 3 or more.
Exclusion criteria
Exclusion criteria: - Previous irradiation overlapping with the intended fields - Stent in situ - Serum DPD deficiency - Prior intravenous chemotherapy for esophageal cancer - An active infection requiring systemic therapy - Has known psychiatric disorders or substance abuse disorders that would interfere with cooperation in the trial - Inability, or serious suspicion of inability to administer the prescribed doses of capecitabine - Is pregnant or breast feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| compliance to treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| locoregional control | — |
Contacts
Public Contactmaarten hulshof
amsterdamumc
Outcome results
None listed