The relevance of donorspecific memory B cells in immunised kidney transplant recipients

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON25271

Enrollment

100

Registered

2014-07-16

Start date

2013-08-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kidney transplant recipients niertransplantatie patiënten

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Patients who will undergo a kidney retransplant and, if applicable, their living kidney donor

Exclusion criteria

Exclusion criteria: Hepatitis C or HIV seropositive individuals

Design outcomes

Primary

Measure	Time frame
The main parameter to be assessed in the current study is the frequency of donor-specific memory B cells as determined by a novel ELISPOT based technique. Furthermore, donor-specific antibody levels will be determined by CDC and Luminex techniques.	—

Secondary

Measure	Time frame
The secondary study parameters are clinical parameters. The transplant function at 6 and 12 months will be determined by the estimated Glomerular Filtration Rate (eGFR), calculated by the Modification of Diet in Renal Disease (MDRD) formula. Furthermore, the occurrence of cellular and antibody mediated rejection within the first year after transplantation will be recorded.	—

Contacts

Public ContactS. Heidt

s.heidt@lumc.nl

Outcome results