Vitamin K, menaquinone-7, arterial calcification, dp-ucMGP, diabetes patiënts, arterial stiffness, bone metabolism.
Conditions
Interventions
Sponsors
UMC Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: - Middle aged men and women ¡Ý 40 years. - Diagnosed with type 2 diabetes. - At high risk of arterial calcification, based on an Ankle Brachial Index (ABI) <0.9 or ¡Ý 1.3 or diagnosed PAD (prevalence is 24% in patients with type 2 diabetes (39)). - Written informed consent
Exclusion criteria
Exclusion criteria: - Contra-indication for undergoing 18F-NaF PET/CT scan (pregnancy, breastfeeding, recent radiotherapy or chemotherapy). - Subject underwent amputation. - Not willing to give up blood donation during the study. - Using vitamin K antagonists. - Known coagulation problems (history of thrombosis). - Using vitamin supplements that contain vitamin K, vitamin D or calcium. - A mean vitamin K2 intake ¡Ý 120 ¦Ìg/day measured with a telephone questionnaire. - Natto or goose liver consumers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial calcifications as quantified by 18F-NaF PET/CT imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Arterial calcification in other arteries than the femoral artery as quantified by 18F-NaF PET/CT imaging. - Bone metabolism in the lumbar spine, as quantified by 18F-NaF PET/CT imaging. - Arterial stiffness, as quantified by pulse wave velocity measurement. - Dpuc-MGP, as quantified using a sandwich ELISA. | — |
Contacts
Public ContactSabine Zwakenberg
Julius Center for Health Sciences and Primary Care -Universitair Medisch Centrum Utrecht
Outcome results
None listed