patients with a small abdominal aneurysm of the aorta.
Conditions
Interventions
patients with an asymptomatic, small aneurysm of the abdominal aorta and healthy male volunteers will visit the hospital 4 times during two years, at an interval of 6 months. During the first visit, p
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: presence of asymptomatic, small AAA, older than 20 years, male or female
Exclusion criteria
Exclusion criteria: 1. A clinical condition which is actual and may interfere with the endpoints of the study (e.g. malignancy, infection/sepsis, chronic inflammatory disease ). 2. The use of drugs with anti-inflammatory properties including prostaglandin synthetase inhibitors, which have been shown to reduce the inflammatory response 3. The use of immunosuppressants, including glucocorticoids, cyclosporine e.g. 4. Ruptured/symptomatic AAAs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The relation between LT levels (in stimulated neutrophils and urine) and annual rate of expansion of small AAAs. 2. Comparison of LT levels between subjects with AAA and normal controls. 3. The association between at-risk gene variant genes involved in 5-LO pathway and AAA growth rate. (4) To assess the presence of neutrophils and 5-LO products in AAA specimens | — |
Secondary
| Measure | Time frame |
|---|---|
| The relation between other inflammatory markers. (e.g. MMP9, hsCRP, MIP-1a, RANTES, MCP-1, CD-40L) and rates of expansion of small AAAs | — |
Contacts
Public ContactL.N. Broekhuizen
Academic Medical Center (AMC), Department of Vascular medicine F4-142 P.O. Box 22660
Outcome results
None listed