Stop study.

Severe Haemophilia: Prophylactic treatment in the 2nd and 3rd decade.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON25201

Enrollment

Registered

2011-10-10

Start date

2011-11-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

haemophilia, prophylaxis, adherence, bleeds, arthropathy. hemofilie, profylaxe, therapietrouw, bloedingen, arthropathie.

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Severe haemophilia A (factor VIII < 0.01 IU/ml); 2. Born between January 1st 1970 and January 1st 1988; 3. Registered at the haemophilia treatment centres in Utrecht (NL), Århus and Copenhagen (DK).

Exclusion criteria

Exclusion criteria: 1. History of inhibitory activity of more than 5 BU at any time or less than 5 BU for more than one year; 2. Inadequate access to treatment during the first years of life (i.e. no access to unlimited replacement therapy during the first 4 years of life, e.g. in case of immigration); 3. Insufficient follow up or insufficient data; 4. Other pathology influencing bleeding pattern.

Design outcomes

Primary

Measure	Time frame
1. Joint status according to Haemophilia Joint Health Score (HJHS) and Pettersson score; 2. Annual number of joint bleeds; 3. Figure 8 walk test.	—

Secondary

Measure	Time frame
1. Clotting factor consumption; 2. Orthopaedic surgery; 3. Hospital admissions in the third decade of life; 4. Major soft tissue bleeds.	—

Contacts

Public ContactKathelijn Fischer

PO Box 85500

K.Fischer@umcutrecht.nl+31 (0)88 7558450

Outcome results