cognition, EEG, vardenafil cognitie, EEG, vardenafil
Conditions
Interventions
The study will be conducted according to a double-blind, placebo-controlled, 3-way cross-over design. Order of treatments (vardenafil 10 mg, vardenafil 20 mg and a placebo) will be balanced over three
Sponsors
Maastricht University
Eligibility
Inclusion criteria
Inclusion criteria: 1. Volunteers who are male or female, 2. 18 to 35 years of age, 3. Healthy (i.e. absence of all exclusion criteria), 4. Normal static binocular acuity (corrected or uncorrected), 5. Body mass index between 18.5 and 30, 6. Willingness to sign an informed consent, 7. Positive evaluation on the screening.
Exclusion criteria
Exclusion criteria: 1. Excluded will be those volunteers who suffer from or have a history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or psychiatric illness. 2. Other exclusion criteria are excessive drinking (>20 glasses of alcohol containing beverages a week), 3. Pregnancy or lactation, 4. Use of medication other than oral contraceptives, 5. Use of recreational drugs from 2 weeks before until the end of the experiment, 6. Any sensory or motor deficits which could reasonably be expected to affect test performance. 7. Those volunteers who have a first-degree relative with a psychiatric disorder or a history of a psychiatric disorder will also be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome is the behavioural score on the memory tests; the verbal learning task (VLT), the spatial memory task (SMT) and the continuous recognition memory task (CRMT). Secondary, the event-related potentials during those tasks will be analyzed. | — |
Secondary
| Measure | Time frame |
|---|---|
| Other important outcomes are the behavioural scores on the Tower of London (TOL) and the Stroop task. In addition, visual and auditory evoked potentials (respectively VEPs and AEPs), which will give an indication of the role of vardenafil in information processing are important measures as well. Finally, the ratio (S2/S1) of the P50 is a measure of sensory gating. | — |
Contacts
Public ContactOlga Reneerkens
Department of Neuroscience Maastricht University PO Box 616
Outcome results
None listed