acute ischemic stroke
Conditions
Interventions
1. IV insulin
2. Continuous tube feeding
3. Vildagliptin.
Sponsors
AMC
Eligibility
Inclusion criteria
Inclusion criteria: 1. Supra-tentorial stroke with a time of onset within 24h before presentation; 2. An acute neurological deficit measurable with the National Institute of Health Stroke Score (see appendix I, NIHSS score) ¡Ý 4 at presentation; 3. Venous plasma admission glucose > 7.0 mmol/l; 4. Informed consent.
Exclusion criteria
Exclusion criteria: 1. Signs of cerebral hemorrhage on computed tomography scan; 2. Previous history of diabetes mellitus treated with insulin; 3. Patients in whom death appears imminent; 4. Renal insufficiency defined as creatinine > 150 mmol/L; 5. Patients under the age of 18; 6. Pregnant patients; 7. Expected transfer to a different hospital within 5 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Glycemic control. (Mean glucose throughout protocol treatment; Percentage of time spent within target range); 2. Hypoglycemia (glucose <3.5 mmol/L): Number of hypoglycemic events per group, Number of serious hypoglycemic events (glucose<2.2 mmol/L), Number of symptomatic confirmed hypoglycemic events. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical outcome (modified Rankin score) at three months; 2. Incidence of pneumonia; 3. Treatment data. | — |
Contacts
Public ContactNyika Kruyt
Academic Medical Center University of Amsterdam P.O. Box 22700
Outcome results
None listed