Vascular function
Conditions
Interventions
ingestion of black tea vs placebo-tea
Sponsors
Department of Physiology, section of Integrative Physiology, Radboudumc Nijmegen
Eligibility
Inclusion criteria
Inclusion criteria: Healthy subjects: - Males and post-menopausal (> 1 years) females - Aged >45 and < 75 years - Body mass index (BMI) between 18.0 and „T35.0 kg
Exclusion criteria
Exclusion criteria: - Regular performance of strenuous exercise/sport of > 2 hours per week - Current smoker or has stopped smoking less than 6 months before start of study - Self reported alcohol intake of >21 units/week) - Established cardiovascular disease - Diabetes mellitus - Blood pressure > 160/100 mmHg - Subjects taking any medication that might affect endothelial function (e.g. but not limited to beta-blockers, ACE-inhibitors, statins, anti-coagulants, anti-depressants, hormone replacement therapy) will be excluded from the study. Subjects who are on stable medication for which there is no indication of an effect on endothelial function, will be allowed to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean forearm blood flow response (volume change measured by venous occlusion plethysmography) to intra-arterially administered acetylcholine (i.e. endothelium-independent vasodilation) | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean forearm blood flow response (volume change measured by venous occlusion plethysmography) to intra-arterially administered sodium nitroprusside (i.e. endothelium-dependent vasodilation); Mean forearm blood flow response (volume change measured by venous occlusion plethysmography) to intra-arterially administered sodium L-NMMA(i.e. nitric oxide-blocker; endothelium-dependent vasoconstriction) | — |
Contacts
Public ContactDick H.J. Thijssen
Phililps van Leijdenlaan 15
Outcome results
None listed