Metabolic effects of morning light.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON25124

Enrollment

Registered

2013-02-25

Start date

2013-03-11

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glucose metabolism

Interventions

Subject will be admitted in the evening and receive a standard meal in normal room light. They sleep for 8 hours in the dark. From wake-up time they consume a standard liquid in bright or dim light.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18-55 years; 2. Male sex; 3. BMI 18-25; 4. Fasting plasma glucose <5.6 mmol/L; 5. Habitual wake-up time between 6:00 and 9:00.

Exclusion criteria

Exclusion criteria: 1. Medication interfering with glucose metabolism or neuronal synaptic transmission; 2. Gastro-intestinal or metabolic disease that will interfere with digestion or metabolism; 3. Neuropsychiatric illness including severe depression; 4. Epilepsy; 5. Hypertension; 6. Ophthalmological abnormalities.

Design outcomes

Primary

Measure	Time frame
To investigate the effect of morning light exposure on postprandial glucose excursions and expression of metabolic and clock genes in adipose tissue.	—

Secondary

Measure	Time frame
To investigate the effect of morning light exposure on postprandial insulin excursions, postprandial free fatty acid (FFA) excursions, postprandial triglyceride levels, morning glucocorticoid increase, morning salivary melatonin decrease and measurements of skin temperature decrease and heart rate variability.	—

Contacts

Public ContactD.J. Stenvers

Room F5-165 Department of Endocrinology and Metabolism Academic Medical Center, Amsterdam

d.j. stenvers@amc.uva.nl+31 (0)20 5663507

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)