overweight obesity weight maintenance polymorphisms Brain plasticity of reward overgewicht obesitas gewichtsbehoud polymorfismen hersenplasticiteit van beloning
Conditions
Interventions
The study has a double blind parallel 2-arm design, with 2 conditions (diets). There are 2 different diets: one that is relatively high in protein and one with normal protein content. The subjects (n=
of these 300, 88 will be assessed in the fMRI to investigate the brain areas involved in plasticity of reward with respect to food.
In total there are three measurement moments: before the weight loss
2. Weight maintenance during which the subjects are assigned to 1 of 2 diets: a relatively high protein diet and a diet with normal protein content.
Sponsors
Maastricht university
Postbus 616
6200 MD Maastricht
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for the whole study are being healthy (no medication use except contraception), both genders, age between 18-55 years, BMI over 25 kg/m2, non-smoker. For the subjects that are included for the fMRI extra inclusion criteria are as follows: not having any metals in the body, being right-handed.
Exclusion criteria
Exclusion criteria: Exclusion criteria are: use of medication (except contraception), extensive alcohol consumption (more than 10 consumptions per week), instable weight (changed more than 5 kilo over the last year), pregnancy, depression, hypertension, kidney dysfunctions and other serious disorders (for example epilepsy, arrhythmia, parkinsonism, insomnia). For the subjects that are included for the fMRI extra exclusion criteria are as follows: having metals in the body, being left-handed and claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Differences in success between the diets (anthropometry measurements); 2. Differences in brain plasticity of reward; 3. Differences in the FTO and TaqIA genes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measurements of hunger suppression using visual analogue scales and ghreline determination. | — |
Contacts
Public ContactMieke Martens
PO Box 616
Outcome results
None listed