Use of preoperative desmopressin in preventing bleeding in patients treated with SSRI's.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON25097

Enrollment

Registered

2005-09-01

Start date

2005-04-07

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

disorder primary hemostasis

Interventions

Preoperative infusion placebo / desmopressin ( 100 kg: 45 mcg).

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients aged over 18 who receive a serotonergic antidepressant (fluvoxamine, fluoxetine, paroxetine, sertraline, venlafaxine, clomipramine, citalopram) at least started two weeks before the surgery; 2. Surgery: orthopedic, abdominal, breast.

Exclusion criteria

Exclusion criteria: 1. No informed consent; 2. Disorder in primary hemostasis; 3. Hyponatremia (sodium (serum) < 130 mmol/l); 4. Laparoscopic surgery; 5. Use of vitamin K antagonists, aspirin, iron supplements, methotrexate, heparin; 6. Acute coronary syndrome (unstable angina and myocardial infarction); 7. Spinal anesthesia during surgery.

Design outcomes

Primary

Measure	Time frame
Peri- and postoperative blood loss.	—

Secondary

Measure	Time frame
1. Pre- and postoperative hemoglobin; 2. Number of perioperative blood transfusion; 3. Perioperative fluid infusion; 4. Postoperative drainage.	—

Contacts

Public ContactS.C. Marczinski

Willy Brandtlaan 10

Marczinskis@zgv.nl+31 (0)318 435546

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)