stroke carotic endarterectomy blood coagulation platelet reactivity beroerte carotis endarteriectomie bloedstolling plaatjesfunctie
Conditions
Interventions
1) 2 bloodsamples at T1 and T2 for Callibrated Automated Thrombogram and for coagulation factors and platet function tests.
2) Transcranial Doppler sonography at T3. The amount of MES are measured d
Sponsors
MUMC
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with an ischemic stroke or TIA (first episode or recurrent disease) AND: an ipislateral stenosis of the carotid artery for which operation of the carotid artery is indicated. 2. Patients need to have an adequate transtemporal window for TCD monitoring og the ateria cerebri media
Exclusion criteria
Exclusion criteria: 1. Proven coagulopathies 2. Pregnancy 3. Active infections 4. Chronic inflammatory diseases 5. Anti-phospholipid syndrome 6. Active malignancy 7. Recent cardiovascular intervention (< 3 months) 8. Cardiac arrythmias 9. Postradiation stenosis of the carotid artery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of MES signals (mean and SD) during TCD monitoring start from the first postoperative hour during a period of 3 hours in relation to thrombogenicity and platelet reactivity | — |
Secondary
| Measure | Time frame |
|---|---|
| - Postoperative stroke in realtion to thrombogeniticity and platlet reactivity during 1 year follow-up - Postoperative stroke (asymptomatic) during 7 days follow-up starting from operation day, detected by MRI | — |
Contacts
Public ContactK. Winckers
University Maastricht Department of Biochemistry K4.360
Outcome results
None listed