Adult patients admitted to the ICU who are mechanically ventilated for >24h.
Conditions
Interventions
Not applicable.
Sponsors
Roche Diagnostics International Ltd
Eligibility
Inclusion criteria
Inclusion criteria: - Aged =18 years - Mechanically ventilated for >24h - Fulfilling readiness-to wean criteria - Written informed consent from the patient or his/her first representative
Exclusion criteria
Exclusion criteria: - Patients with risk factors for laryngeal oedema and a negative cuff leak test, performed after a successful SBT (indicating upper airway obstruction with need for steroid treatment) - Planned replacement of the endotracheal tube for a tracheostomy - Terminal illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extubation failure within 48 hours, composed of: -Reintubation, or -Rescue non-invasive ventilation or high-flow nasal oxygen for post-extubation respiratory insuf-ficiency, or -All-cause mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| - Extubation failure within 72h and 1 week - ICU length of stay post-extubation for medical reasons - ICU re-admission rate within current hospitalisation - All-cause mortality: ICU, 28-days, hospital, 3 and 12 months - Long-term follow-up at 3 and 12 months: major adverse cardiovascular events (total death, myocardial infarction, coronary revascularization, stroke, and hospitalization because of heart failure or arrhythmia), Quality of life (RAND-36 and EQ-5D). | — |
Contacts
Public ContactVivan Baggen
Erasmus MC
Outcome results
None listed