Sleep efficiency, growth, nutritional status, inflammatory markers. Slaap efficientie, groei, voedingskundige status, ontstekings indicatoren.
Conditions
Interventions
A. Current formulae for preterm infants during the hospital phase (till 3500 g of body weight)
B. Preterm formulae with protein hydrolysate, and increased levels of some vitamins and minerals in accordance with the ESPGHAN guidelines.
Sponsors
Specialized Hospital for Active Treatment of Children’s Disease, Sofia, Bulgaria
Eligibility
Inclusion criteria
Inclusion criteria: 1. Apparently healthy infants, appropriate for gestational age (AGA); 2. Gestational age of 32 up to but not including 35 (ongoing) weeks; 3. Full enteral nutrition; 4. Not younger than 2 or older than 3 weeks of age at inclusion; 5. Bottle fed; 6. Being able and willing to drink milk; 7. No medical recognized mental problems.
Exclusion criteria
Exclusion criteria: 1. Human milk consumption; 2. Congenital malformations or conditions known to affect growth (e.g. severe broncho pulmonary dysplasia, inborn error of metabolism, cardiac or renal disease, necrotizing enterocolitis with substantial gut loss, and grade IV intraventricular hemorrhage); 3. Lactose intolerance; 4. Familiar history of impaired iron metabolism (haptoglobin Hp2-2, hemochromatosis, sickelcell anemia, thalassemia); 5. Medications that may effect digestion or absorption of food, or affect sleep; 6. Blood transfusions; 7. Vitamin supplements during the intervention period.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory markers in blood and urine. | — |
Primary
| Measure | Time frame |
|---|---|
| 1. Growth; 2. Sleep efficiency; 3. Nutritional status of iron, vitamin D, vitamin A, folic acid, and DHA-AA. | — |
Contacts
Public ContactAnne Schaafsma
P.O.Box 226
Outcome results
None listed