Recurrence or Relapse of Major Depression Disorder
Conditions
Interventions
Short-term continuation PCT (C-PCT) consist of 8 sessions that is offered as sequential treatment after response to A-CT. The effectiveness of C-PCT has been evaluated in earlier trials (Bockting et a
2009).
CT is directed at the identification of maladaptive cognitions and the development of a personal prevention strategy. C-PCT (Bockting et al., 2009) is an adapted type of cognitive therapy spe
Sponsors
Arkin, mental health care institute Amsterdam,
Department of Psychology of the University of Groningen,
Vanderbilt University, Nashville,
Vrije Universiteit Amsterdam, Faculteit der Geneeskunde Huisarts- en Verpleeghuisgeneeskunde,
Trimbos Instituut, Innovation Centre of Mental Health & Technology,
Vrije Universiteit Amsterdam, Faculteit der Aard- en Levenswetenschappen Gezondheidswetenschappen: Health Economics and Technology Assessment
Eligibility
Inclusion criteria
Inclusion criteria: 1. Two or more previous depressive episodes indicating high risk for relapse/recurrence; 2. In remission according to DSM-IV criteria; 3. A current score of <14 on the Hamilton Rating Scale for Depression; 4. During the acute phase of the last episode, patients received CT at the Arkin Mental Health Care Institute.
Exclusion criteria
Exclusion criteria: 1. Current mania or hypomania or a history of bipolar illness; 2. Any psychotic disorder (current and previous); 3. Alcohol or drug misuse; 4. Predominant anxiety disorder; 5. Insufficient mastering of the Dutch language.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is the cumulative proportion of relapses/recurrences in a survival-analysis over a follow-up period of 15 months after the start of the preventive therapy as measured with the ‘Structural Interview for DSM-IV (SCID) using the Longitudinal Interval Follow-up Evaluation (LIFE), which provides a retrospective assessment of depression recurrences since the time of the last evaluation. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The severity of depressive symptoms as measured with the 'Inventory of Depression Symptomatology' (IDS-SR); 2. Number of relapses (SCID); 3. Anxiety (SCID); 4. Suicidal thoughts (SCID); 5. Social and interpersonal functioning (IIP); 6. Well-being, quality of life (EQ-5D); 6. Consumption of mental health care and degree of work absence (TIC P). | — |
Contacts
Public ContactJ. Dekker
Department of Rehabilitation Medicine, VUmc PO Box 7057
Outcome results
None listed