The microlesion effect on cognition after Deep Brain Stimulation in Parkinson’s Disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON25026

Enrollment

Registered

2020-01-24

Start date

2020-05-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Adult that are selected for DBS in the STN by the multidisciplinary working group - Oral- and written informed consent

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Unstable internal or other pathologies - Not able to apprehend the consequences of surgical intervention - Depression or other psychiatric instabilities - Dementia (Mattis Dementia Rating Scale (DRS) <120 or Scales for Outcomes of Parkinson’s disease-cognition (SCOPA-Cog) <20)

Design outcomes

Primary

Measure	Time frame
The primary endpoints of the study are the SDMT, Stroop and WAIS part IV Digit Span scores to assess the MLE on cognitive functioning	—

Secondary

Measure	Time frame
The MoCA score on the day before the surgery and at 6 months, to assess the predictive value of perioperative cognitive functioning (MoCA scores are correlated to SDMT, Stroop and WAIS part IV Digit Span scores to assess this topic).	—

Contacts

Public ContactNaomi Kremer

University Medical Center Groningen

n.i.kremer@umcg.nl+31 652174838

Outcome results