None listed
Conditions
Interventions
Healthy volunteers:
Phase 1: Observe respiratory rate under normal breathing conditions and with a 50% increase and decrease in respiratory rate
Phase 2: Observe respiratory rate and SpO2 after an iv single bolus of remifentanil (50 ug/70 kg) under normal are conditions and with 50% oxygen.
Postoperative patients:
Phase 3: Observe respirator
Sponsors
Leiden University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: Healthy volunteers and post-operative patients being able to give informed consent.
Exclusion criteria
Exclusion criteria: For healthy volunteers: 1. Obesity (BMI > 35); 2. Presence of medical disease (heart-, lung-, liver-, kidney-, neurologic disease; diabetes m.; pyrosis; diaphragmatic hernia); 3. Presence of psychiatric disease; 4. History of chronic alcohol or illicit drug use; 5. Allergy to study medications; 6. Expected difficulty to hold to subject on mask causing leakage and inability to perform mask ventilation (i.e., Mallampati classification 3 or greater); 7. For females, we require the use of contraceptives. For post-opartive patients: Presence of cardiopulmonary diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Respiratory rate measured by the Respir8, the stopwatch method, capnography and ECG; 2. Oxygen saturation. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes will be measured in this study. | — |
Contacts
Public ContactAlbert Dahan
Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600
Outcome results
None listed