Effect of hyperglycemia on the ventilatory response to hypoxia

INFLUENCE OF HYPERGLYCEMIA ON THE VENTILATORY RESPONSE TO ISOCAPNIC HYPOXIA A Clinical Study in Healthy Volunteers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON25005

Enrollment

Registered

2008-03-21

Start date

2008-06-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Control of breathing/physiology

Interventions

Our primary outcome is the ventilatory response to hypoxia. To that end, hypoxia will be induced by lowering the inspired oxygen concentration using a computer-controlled dynamic end-tidal forcing sy

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy volunteers in the age group of 18 years - 45 years

Exclusion criteria

Exclusion criteria: 1. Obesity (BMI > 30) 2. Presence of medical disease (heart-, lung-, liver-, kidney-, neurologic disease; diabetes m.; pyrosis; diaphragmatic hernia) 3. Presence of psychiatric disease 4. History of chronic alcohol or drug use 5. Allergy to study medications 6. Possibility of pregnancy 7. Lactation

Design outcomes

Primary

Measure	Time frame
The ventilatory response to hypoxia in terms of delta(ventilation)/delta(lopPaO2)	—

Contacts

Public ContactAlbert Dahan

Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600

a.dahan@lumc.nl+31 (0)71 5262301

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)