Intraoperative cardiac monitoring, left ventricular function
Conditions
Interventions
Besides standard intraoperative monitoring, patients will receive the following:
1. Transoesophageal echocardiography
2. Continuous noninvasive finger blood pressure measurements using the Nexfin
3. Inferior Vena cava occlusion for 15 seconds
4. Administration of Fenylephrine intravenously.
Sponsors
VU University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for: A. Open abdominal surgery via laparotomy; B. Cardiac surgery, Coronary Artery Bypass Graft. 2. Age 18-75 years; 3. Informed consent.
Exclusion criteria
Exclusion criteria: Group A specific: 1. Known / documented cardiac disease; 2. ECG / echocardiography abnormalities. All subjects group A + B: 1. Contraindications for TEE; 2. Contraindications for arterial line; 3. Contraindications for administration of phenylephrine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Is it possible to reconstruct intraoperative left ventricular end-systolic pressure-volume relations from a combination of non-invasive finger arterial blood pressure measurements and transesophageal echocardiography in patients undergoing surgery? | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. What is the relation of dicrotic notch pressure in the aortic pressure curve to beat average pressure? 2. Loading changes to construct the end systolic pressure-volume relation are commonly induced by reducing preload using inferior vena cava compression. Does increasing afterload using phenylephrine-induced vasoconstriction provide an alternative for inferior vena cava compression? | — |
Contacts
Public ContactR.A. Bouwman
Outcome results
None listed