Acute Myocardioal infarction, rescue PCI, prehospital treatment. Myocard infarkt Hartinfarkt
Conditions
Interventions
5 mg intravenous Metoprolol or matching placebo before reperfusion in the ambulance.
Sponsors
Maatschap Cardiologie Isala klinieken Zwolle
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients ≥ 18 years of age with symptoms of acute ST-elevation myocardial infarction of more than 30 min but less than 12 hours and on the ECG ST-segment elevation of ≥0.1 mV in two adjacent limb electrocardiograph (ECG) leads and ≥0.2 mV in two adjacent precordial ECG leads or new left bundle branch block (LBBB). 2. Verbal followed by written informed consents. 3. PCI-center located within 90 minutes
Exclusion criteria
Exclusion criteria: 1. Severe Hypotension (systolic blood pressure 110/min) 3. Known with asthma 4. Severe bradycardia at sinusrythm (240 ms or second- and/or third degree atrio-ventricular (AV) block 6. History of previous myocardial infarction 7. Killip class III-IV 8. Pacemaker/implantable cardioverter defibrillator (ICD) 9. Unable to provide informed consent 10. Patient is pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infarct size as measured by MRI 1 month post MI. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Troponin-T after 24 hour of hospitalization 2. Peak CK within hospitalization period 3. Area under CK and CK-MB curve within hospitalization period. 4. Residual ST deviation 1 hr after CAG/PCI 5. Ventricular Fibrillation requiring defibrillation during transportation and hospitalization 6. MACE at 30 days and one year FUP Safety End Points: 1. The incidence of severe bradycardia, asthma or cardiogenic shock 2. 30 day and one year total mortality | — |
Contacts
Public ContactSonja Postma
Dokter Stolteweg 96
Outcome results
None listed