Tourette syndrome Tics
Conditions
Interventions
None
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: ONSET: • First degree relative of person with TS or another chronic tic disorder according to DSM IV-TR criteria (American Psychiatric Association). This may include children with a half-sister/-brother with a tic disorder. • Aged 3-10 years, male or female Parents and patients have provided written informed consent and assent as appropriate according to ethical regulation COURSE: • TS or another chronic tic disorder according to DSM IV-TR criteria (American Psychiatric Association) • Age 3 through 16 years, male or female • Parents and patients have provided written informed consent and assent
Exclusion criteria
Exclusion criteria: ONSET: • Presence of tics. This will be checked by using the tic check list of the YGTSS. • Current or previous presence of OCD • Current or previous presence of trichotillomania • Serious medical illness • Child treated with antibiotics in the past 1 month. • Children and/or parents are unable to understand and comply with protocol. COURSE: • Serious medical illness • Child treated with antibiotics in the past 1 month • Children and/or parents are unable to understand and comply with protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study outcome is onset of tics (ONSET study) and tic exacerbation (COURSE study), as assessed by the Yale Global tic severity scale (YGTSS) plus Premonitory Urge for Tics Scale (PUTS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters are the presence of obsessive-compulsive symptoms as assessed by the Children’s Yale Brown Obsessive-Compulsive Scale (CY-BOCS) and the presence of GAS in throat swabs. | — |
Contacts
Public ContactP.J. Hoekstra
University Medical Center Groningen Hanzeplein 1
Outcome results
None listed