vascular endothelium dysfunction, dysfunction arteries, skeletal muscle, blood volume changes.
Conditions
Interventions
The study is designed as a prospective observational study without invasive measurements on healthy subjects. After informed consent is obtained a baseline assessment will be performed. This assessmen
Sponsors
Máxima Medisch Centrum
Eligibility
Inclusion criteria
Inclusion criteria: Written informed consent Age 18-50 years. Able to perform a maximal exercise test.
Exclusion criteria
Exclusion criteria: Subjects with risk of adverse events according to abnormal findings in physical examination or the Lausanne questionnaire. Orthopaedic,cardio-vascular, pulmonary, neuromuscular and other diseases limiting exercise capacity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reproducibility: Difference and agreement (bias and limits of agreement) of changes in blood volume assessed by power Doppler in the vastus lateralis muscle during maximal and submaximal exercise on two separate days. | — |
Secondary
| Measure | Time frame |
|---|---|
| Validity: - Correlation between changes in power Doppler-signal in the musculus vastus lateralis and changes in blood flow in the afferent artery measured with pulsed wave Doppler during exercise. - Correlation between changes in total hemoglobulin measured with near infrared spectroscopy and changes in Power Doppler-signal during exercise. | — |
Contacts
Public ContactThijs Schoots
Máxima Medisch Centrum (department Cardiology)
Outcome results
None listed