osteoporosis fracture cognitive decline physical performance quality of life nutritional status
Conditions
Interventions
- 500 µg vitamin B12 and 0.4 mg folic acid in one capsule, once per day
- placebo capsule, once per day
Sponsors
Wageningen University, Divison of Human Nutrition
Eligibility
Inclusion criteria
Inclusion criteria: 1. 65 years and older; based on entry date into study; 2. Fasting plasma Hcy level >= 12 µmol/L and 85%; 7. Serum creatinine >150 µmol/L.
Exclusion criteria
Exclusion criteria: 1. Participation in other intervention trials; 2. Serious medical conditions, e.g. cancer diagnosis within the last 5 years or recent myocardial infarction; 3. Immobilization (bedridden, wheelchair bound)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fracture incidence | — |
Secondary
| Measure | Time frame |
|---|---|
| - falls - quantitative ultrasound (QUS) - bone turnover - BMD - incidence of cardiovascular events or diagnosis of cancer - physical performance - cognitive decline - quality of life | — |
Contacts
Public ContactLisette Groot, de
Wageningen University, Division of Human Nutrition, P.O. Box 8129
Outcome results
None listed