Pain, pain relief. Pijn, pijnbehandeling, analgesie
Conditions
Interventions
The study has a double-blind, cross-over, placebo-controlled design. During Session X, the subjects will receive an intravenous bolus dose of fentanyl (150 mug/70 kg) at time t = 0 during the backgrou
naloxone dose = 3 mg bolus followed by 3 mg/h). Next at 5-15 min intervals the response to 48-50 oC heat pain stimulus (using the TSA II device, Medoc, Israel) applied to the lower arm will be obtaine
Sponsors
LUMC, Dept. of Anesthesiology
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy volunteers 18-45 years
Exclusion criteria
Exclusion criteria: 1. Obesity (BMI > 30) 2. Presence of medical disease (heart-, lung-, liver-, kidney-, neurological disease; diabetes m.; pyrosis; diaphragmatic hernia) 3. Presence of psychiatric disease 4. History of chronic alcohol or drug use 5. Allergy to study medications 6. Possibility of pregnancy 7. Lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain relief in response to a heat pain stimulus to the arm | — |
Contacts
Public ContactAlbert Dahan
Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600
Outcome results
None listed