PROPOSE : PReoperative Optimization of Pharmacotherapy in frail Older patients with use of STRIP assistant.

Preoperative optimization of pharmacotherapy in frail older patients with polypharmacy with the use of STRIP assistant: a clustered randomized trial.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24922

Enrollment

100

Registered

2016-02-12

Start date

2014-10-13

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who are visiting the outpatient clinic for a preoperative geriatric screening. They are planned for elective otorhinolaryngological, oral, maxillofacial, cardial, gynecological or colorectal surgery.

Interventions

The intervention consists of a written pharmacotherapeutic advice, which will be generated by application of the STRIP assistant. The STRIP Assistant is an online software system (i.e. electronic vers

Eligibility

Inclusion criteria

Inclusion criteria: Age above 70 years with polypharmacy (5 of more different drugs) and planned for elective otorhinolaryngological, oral, maxillofacial, cardial, gynecological or colorectal surgery

Exclusion criteria

Exclusion criteria: Exclusie criteria: Patients under the age of 70 years. No polypharmacy. When information about the use of drugs was not available before the visit at the outpatient clinic.

Design outcomes

Primary

Measure	Time frame
The primary outcome measure is the efficacy of the use of the STRIP assistant as a tool for polypharmacy optimization in addition to usual care in frail elderly patients in the clinical setting. The efficacy will be defined as the number of Potentially Inappropriate Medications (PIM’s) and Potentially Prescribing Omissions (PPO’s) identified per patient, compared to the ‘usual care’.	—

Secondary

Measure	Time frame
The number of missed, inadequate and potential deleterious advices will also be reported. Also, well-known ADRs, interactions and dose adjustments will be noted. Moreover, we want to investigate whether preoperative optimization of polypharmacy involving the STRIP assistant in older patients positively affects the postoperative morbidity, functionality and mortality 3 months and 1 year postoperatively when compared to the usual care. To determine whether the intervention can define PIMs and PPOs, the preoperative medication will be independently reviewed on appropriateness (i.e. presence of PIM’s and PPO’s) by an expert panel in a selection of patients from both groups. This panel consists of at least a geriatrician/pharmacologist and a pharmacist/pharmacologist and will also evaluate the number of appropriate, indifferent or potential harmful decisions.	—

Measure

Time frame

The number of missed, inadequate and potential deleterious advices will also be reported. Also, well-known ADRs, interactions and dose adjustments will be noted. Moreover, we want to investigate whether preoperative optimization of polypharmacy involving the STRIP assistant in older patients positively affects the postoperative morbidity, functionality and mortality 3 months and 1 year postoperatively when compared to the usual care. To determine whether the intervention can define PIMs and PPOs, the preoperative medication will be independently reviewed on appropriateness (i.e. presence of PIM’s and PPO’s) by an expert panel in a selection of patients from both groups. This panel consists of at least a geriatrician/pharmacologist and a pharmacist/pharmacologist and will also evaluate the number of appropriate, indifferent or potential harmful decisions.

—

Contacts

Public ContactMarijke Boersma,

UMCU - afdeling geriatrie

M.N.Boersma-2@umcutrecht.nl088-7558295

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)