ketamine
Conditions
Interventions
Ventilation will be elevated by isohypercapnic ventilation to 20L/min, if a steady-state is reached, there will be started with remifentanil. The ventilation will be decreased with 40-50%. After reach
Sponsors
LUMC
Eligibility
Inclusion criteria
Inclusion criteria: - Healthy male or female volunteers; - Age: 18 - 40 years; - Body mass index < 30 kg/m2; - Able to give informed consent.
Exclusion criteria
Exclusion criteria: - Known or suspected neuromuscular or a (family) history of any neuromuscular disease; - A history of allergic reaction to food or medication including study medication; - Any current or previous medical (including high blood pressure), neurological or psychiatric illness (including a history of anxiety); - Alcohol abuse (> 21 units/week); - Illicit drug use in the past 30 days before inclusion; - Pregnancy or lactation; - Participation in any medical or drug trial in the month prior to the current study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - effect of ketamine on ventilation after OIRD. | — |
Secondary
| Measure | Time frame |
|---|---|
| - effect of ketamine on ventilation - arterial blood sampling for PK - hemodynamic effect | — |
Contacts
Public ContactAlbert Dahan
Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600
Outcome results
None listed