coronary artery disease
Conditions
Interventions
Coronary computed tomography angiography
Invasive Coronary angiography
Sponsors
Academisch Medisch Centrum
Eligibility
Inclusion criteria
Inclusion criteria: Patients receiving clinically indicated CCTA, without anginal complaints and without a history of coronary artery disease (i.e. referred for cardiac valve surgery, patients with ventricular tachycardia or reduced left ventricular function)
Exclusion criteria
Exclusion criteria: - Anginal complaints or acute coronary syndrome - History of CAD - Subjects referred for TAVI procedure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Diagnostic yield of using CCTA as gatekeeper for CAG, in patients without history of CAD and without anginal complaints. - Diagnostic agreement of CCTA for the assessment of significant (>50% stenosis) obstructive coronary artery disease, using invasive coronary angiography measurements as the reference standard. | — |
Secondary
| Measure | Time frame |
|---|---|
| - The cumulative incidence of myocardial infarction, hospital admission for suspected acute coronary syndrome or unstable angina pectoris, revascularization procedures (PCI, CABG), coronary angiography without revascularization and death, from day 1 to 1 year after procedure. - Evaluation of patient acceptance, measured by a patient acceptance questionnaire. - Cost-effectiveness of using CCTA as gatekeeper for CAG in patients without history of CAD and without anginal complaints. - Cumulative contrast dose from either CCTA and CAG - Cumulative incidence of complications related to CCTA and CAG | — |
Contacts
Public ContactThomas Boogert, van den
TKs0-248
Outcome results
None listed