general surgery patients, heart valve replacement, peri/post operative bleeding problems algemene chirurgie patiënten, hartklep vervanging, peri/post operatieve bloedingsproblemen
Conditions
Interventions
Comparing FFP transfusion in massive bleeding patients with the combination of fibrinogen and FFP/DDAVP
Sponsors
dr. JWM. Heemskerk
P.I. CARIM
Eligibility
Inclusion criteria
Inclusion criteria: 1. General surgery patients with massive peri-operative bloodloss, with an indication of receiving 4 units of FFP according to current guidelines. 2. Cardiothoracic surgery patients after heart valve replacement who met the criteria of increased bloodloss and indication for DDAVP.
Exclusion criteria
Exclusion criteria: 1. No other therapeutical anti-thrombotica are given, other than platelet-aggregation inhibitors 2. Patients with active HIV-infection 3. Patients who received FFP or fibrinogen just before the surgery 4. Patients who are hypotherm ( 2 g/L
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stop of bleeding after the therapy. The clinical situtation after the treatment will be compared with conventional coagulation tests (aPTT, PT, fibrinogen level). | — |
Secondary
| Measure | Time frame |
|---|---|
| Thrombin generation and thromboelastography measurements, measured with the CAT en TEG method. | — |
Contacts
Public ContactM. Pampus, van
University Medical Center Gronigen (UMCG), Department of Obstetrics and Gynecology, CMC5, Y4.179, P.O. Box 30001
Outcome results
None listed