Ability of a Parkinson’s patient to use the inhaler correctly during off periods.
Conditions
Interventions
testing if they can generate a sufficiently large airflow and volume through a test inhaler.
Sponsors
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Mathematics and Natural Sciences, University of Groningen
Eligibility
Inclusion criteria
Inclusion criteria: Predictable off periods. Recognizable off periods for themselves and others. At least 2 years of levodopa use. Signed informed consent. Diagnosed with Parkinson’s disease according to the UK Parkinson’s disease society Brain Bank Clinical Diagnostic Criteria
Exclusion criteria
Exclusion criteria: Cognitive dysfunction, which precludes good understanding of instructions and/or informed consent. Current treatment with apomorphine or duodopa by pump. Any chronic pulmonary disease; (asthma, copd, pulmonary fibrosis, pulmonary emphysema, pulmonary gas diffusion disorders, etc). Lung cancer or a history of lung cancer (if not cancer free for at least 5 years).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The parameter that describes whether or not a Parkinson’s patient is capable of using the inhaler correctly is the pressure drop (s)he creates over the inhaler upon inhalation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Peak and mean inspiratory flow rate (PIFR and MIFR). Acceleration towards peak inspiratory flow rate (flow increase rate: FIR). Inhaled volume. Total inhalation time. | — |
Contacts
Public ContactM. Luinstra
RVE klinische farmacie Van Swietenplein 1 Postbus 30033
Outcome results
None listed