Effects of weight loss on stimulated lipolysis.

Effects of weight loss on adipose tissue β2-AR-stimulated lipolysis: Role of adipose tissue oxidative stress and hypoxia.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24842

Enrollment

Registered

2011-08-10

Start date

2011-07-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, beta2-adrenergic sensitivity, lipolysis Obesitas, beta2-adrenerge gevoeligheid, lipolyse

Interventions

Subjects follow the standard weight loss programme in Heerlen (NL) provided by CO-EUR without interference by the researchers. CO-EUR is an obesity treatment centre which uses an 18-month-lasting pr

Eligibility

Inclusion criteria

Inclusion criteria: 1. All subjects entering the Co-Eur programme; 2. Age > 18 years old; 3. No more than 3 kg weight change in the past 3 months.

Exclusion criteria

Exclusion criteria: 1. Smoking; 2. Diabetes; 3. (Medicinal) use of β-blockers or β-agonists; 4. Pregnant women; 5. Blood clotting problems or (medicinal) use of anticoagulantia.

Design outcomes

Primary

Measure	Time frame
Changes in sensitivity to β2-AR-stimulated lipolysis in adipocytes isolated from subcutaneous adipose tissue biopsies.	—

Secondary

Measure	Time frame
1. Changes in markers of adipose tissue hypoxia; 2. Changes in markers of adipose tissue and systemic oxidative stress.	—

Contacts

Public ContactK.F.M. Teunissen-Beekman

Maastricht University Dep. Human Biology P.O. Box 616

kfm.teunissen@maastrichtuniversity.nl+31 (0)43 3881635

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)