Study of B cell functions in multiple sclerosis.

Study of the antibody dependent and independent B cell functions in multiple sclerosis.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON24833

Enrollment

160

Registered

2012-09-24

Start date

2012-03-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

multiple sclerosis, B cells

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Blood samples (10-15ml) are collected from healthy individuals, multiple sclerosis (MS) patients and neurologic control patients. Cerebrospinal fluid (5-10ml) is obtained via lumbar puncture from MS patients and neurologic controls. The lumbar puncture and blood puncture is done in order to get a correct diagnosis. In this way, trouble and risk for the patient is minimal. During this routine puncture, an extra volume is taken for this study. When the diagnosis is different from MS, the patient will be included in the control population. We aim to include 10 patients with a clinically isolated syndrome, 130 MS patients, 80 control patients and 80 healthy controls.

Exclusion criteria

Exclusion criteria: N/A

Design outcomes

Primary

Measure	Time frame
Knowledge on the role of B cells in the disease pathogenesis of multiple sclerosis. This will be through in vitro cultivation and measurement of certain receptors.	—

Contacts

Public ContactVeerle Somers

Biomedical Research Institute Hasselt University

veerle.somers@uhasselt.be+32 11269202

Outcome results