anorexia nervosa
Conditions
Interventions
single donor fecal transplantation from female donor with BMI of 25 kg/m2 (allogenic) or own (autologous)
Sponsors
amc
Eligibility
Inclusion criteria
Inclusion criteria: - Caucasian female - Older than 18 years - BMI <17 kg/m2 - Stable medication use - Meeting the DSM V criteria for anorexia nervosa, restricting type - able to give informed consent
Exclusion criteria
Exclusion criteria: - PPI and antibiotics use in last 3 months - Smoking, XTC, amphetamine or cocaine abuse - Alcohol abuse (>3/day) - A concomitant severe psychiatric disorder, such as psychosis, severe depression or a personality disorder that renders them unsuitable for the trial as judged by a psychiatrist - Participation in a research protocol involving radiation exposure in the last 2 years. - Contraindication MRI (pregnancy, pacemaker and metals contraindicated for MRI). - Cholecystectomy - Expected prolonged compromised immunity (due to recent cytotoxic chemotherapy or HIV infection with a CD4 count < 240) - Treatable underlying cause of anorexia/underweight
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the effect of FMT on different microbiota composition in relation to weight, appetite/satiety (fMRI/questionnaires) and Nutrient Drink Test ( incl plasma hormones) | — |
Secondary
| Measure | Time frame |
|---|---|
| the effect of FMT on difference in resting energy expenditure (REE), physical activity energy expenditure (PAEE) , serotonin metabolism, body composition (Body Impedance Analysis, BIA) and Psychological questionnaires | — |
Contacts
Public ContactM. Nieuwdorp
AFDELING INWENDIGE GENEESKUNDE AMC MEIBERGDREEF 9, KAMER F4.159.2
Outcome results
None listed