asthma bronchial hyperresponsiveness exercise induced asthma
Conditions
Interventions
A single shot (200µg) of beclomethasone and 4 weeks of treatment with beclomethasone, 200µg twice daily.
Sponsors
Medisch Spectrum Twente, Enschede, the Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age between 12-18 years; 2. Clinical history of allergic asthma and exercise induced bronchoconstriction; 3. Ability to perform reproducible lung function tests (predicted value variation in 3 of 5 consecutive measurements 70% of predicted value.
Exclusion criteria
Exclusion criteria: 1. Other pulmonary or cardiac illnesses; 2. Maximal FEV1 < 70% of predicted value; 3. Use of nasal or systemic corticosteroids, antihistamines, cromoglycates, anticholinergics or leukotriene antagonists in two weeks prior to or during the study; 4. Use of long acting bronchodilator agents 24 hours before testing; 5. Use of short acting bronchodilator agents 8 hours before testing; 6. Hospitalization due to asthma exacerbation in past month; 7. Other changes in asthma medication during treatment period; 8. Upper or lower respiratory tract infections during treatment period; 9. Deviation of the FEV1 before the subsequent mannitol challenges of more than 12 % from baseline FEV1.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The correlation between the effect of a single dose of beclomethasone on a mannitol challenge and the effect of 4 weeks of treatment on a mannitol challenge. | — |
Secondary
| Measure | Time frame |
|---|---|
| There will be tested for confounders for this correlation, such as age, gender and baseline lungfunction. | — |
Contacts
Public ContactE.T.G. Kersten
Postbus 50.000
Outcome results
None listed