Sudden caridac Death (SCD), implantable cardiac device (ICD), Dialysis patients, risk factors for sudden cardiac death
Conditions
Interventions
After patient has signed informed consent he will be invited to the LUMC for the assessment of an MSCT, TTE, pulse wave velocity of the aorta, laboratory tests and quality of life score list. A MSCT i
Sponsors
Leids University Medical Center (LUMC)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients 55 to 80 years of age; 2. End Stage Renal Disease (ESRD); 3. > 90 days after start dialysis.
Exclusion criteria
Exclusion criteria: 1. Possible living kidney donation; 2. Terminal congestive heart failure according NYHA class 4 at time of randomization; 3. Non arrhythmic medical condition making 1-year survival unlikely; 4. Excessive perioperative risk for ICD implantation; 5. HIV infection; 6. Patients with central venous line; 7. Acute Myocardial Infarction (AMI) last 40 days; 8. ICD indication according current guidelines; 9. Expected poor compliance with protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine whether ICD therapy in dialysis patients aged 55-80 years results in significant reduction in sudden cardiac (arrhythmic) death rates when compared to no ICD therapy. Cause of death will be classified as being caused by arrhythmia, other cardiac, vascular noncardiac, or nonvascular. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To determine that prophylactic ICD therapy will result in reduction of all cause mortality in dialysis patients; 2. To assess the incidence and types of ventricular and supra ventricular arrhythmias; 3. To assess the relation with LVH, CAC and arterial stiffness and cardiovascular and sudden cardiac death; 4. To assess the safety, costs and quality of life, of ICD therapy in dialysis patients. | — |
Contacts
Public ContactL.C.R. Hensen
Leiden University Medical Center Department of Cardiology C5-P
Outcome results
None listed