Atrial fibrillation, hypertension
Conditions
Interventions
Control group
These patients will undergo PVI
Interventional group
These patients will undergo RDN and PVI
Sponsors
Isala klinieken, department of Cardiology, Zwolle
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: The patient falls within the target group resistent hypertension or symphatic overdrive Patient is an acceptable candidate for renal denervation treatment Patient <75 years
Exclusion criteria
Exclusion criteria: Contraindication to chronic anticoagulation therapy or heparin Previous left heart ablation procedure for AF Acute coronary syndrome, cardiac surgery, PCI or stroke within 3 months prior to enrolment Renal artery stenosis >50% of the arterial lumen, or renal artery lumen >=3 mm
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first detection of atrial fibrillation (AF) >30 seconds, with the monitoring period starting 3 months after the intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| AF burden after 12 months of follow-up, expressed in % of the monitoring period, in patients with continuous rhythm monitoring. The monitoring period starts 3 months after the intervention. Blood pressure at 3, 6, 12 months after the intervention, and change in blood pressure compared to measurement before the intervention Blood pressure and heart rate response changes induced by exercise testing Changes in heart rate variability measures tested by Holter monitoring compared to measurement before the intervention Changes in arterial stiffness measures post intervention AASI (ambulatory arterial stiffness index) by ambulatory blood pressure monitoring, PWV (pulse wave velovity) and augmentation index compared to measurement before the intervention | — |
Contacts
Public ContactGery de Jong
Diagram B.V.
Outcome results
None listed