(pre)malignant cervical laesions, Cervical Intraepithelial neoplasia (CIN), Human Papillomavirus (HPV), long term In Dutch: (pre)maligne afwijkingen cervix, CIN, Humaan papillomavirus (HPV), lange termijn
Conditions
Interventions
All women are invited to the outpatient clinic, where a blood sample and a cervical smear for cytology and HPV testing will be taken.
If the HPV test is HPV positive or if cytology is abnormal a seco
Sponsors
HUMAVAC (VU University Medical Center)
Eligibility
Inclusion criteria
Inclusion criteria: All subjects must satisfy the following criteria at study entry: 1. Previous participation in the following study: 'Relation of human papillomavirus status to cervical lesions and consequences for cervical screening: A prospective study'. 2. Written informed consent prior to enrolment. 3. Sufficient knowledge of the Dutch or English language. 4. The intention to comply with the requirements of the protocol.
Exclusion criteria
Exclusion criteria: 1. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraepithelial Neoplasia (CIN) 2 or 3 and adenocarcinoma in situ (AIS), diagnosed after a follow up period of up to 18 years after an abnormal cervical smear. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study outcomes include: - the results of cervical cytology - the presence of hrHPV - type of hrHPV - serum E6/E7 antibody level - the results of the questionnaire (including sexual behavior, smoking and previous vaccination) - histology results of all endocervix samples and biopsies taken | — |
Contacts
Public ContactM. Kocken
VU university Medical Center room 6Z162 P.O. Box 7057
Outcome results
None listed