Diagnostic efficiency and accuracy, embryonic development and clinical outcome after the biopsy of one or two blastomeres for preimplantation genetic diagnosis.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON24785

Enrollment

592

Registered

2007-02-27

Start date

2001-01-05

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1. Preimplantation genetic diagnosis (NLD: preimplantatie genetische diagnose)

Interventions

Embryos were obtained from patients undergoing PGD. One or two cells were removed from embryos with more than 6 cells at day 3. Embryos shown to be free of disease were replaced in the uterus. Some s

Eligibility

Inclusion criteria

Inclusion criteria: PGD cycles for monogenic diseases, sexing or screening in which one or two cells can be removed from the embryos.

Exclusion criteria

Exclusion criteria: PGD where two cells must be removed for accurate diagnosis: monogenic cycles where PCR for one locus is carried out, or PGD for translocation carriers.

Design outcomes

Primary

Measure	Time frame
1. Embryo transfer rate; 2. Positive hCG; 3. Implantation rate; 4. Live birth rate.	—

Secondary

Measure	Time frame
1. In-vitro embryonic development after the removal of one or two blastomeres; 2. The diagnostic efficiency of both PCR- and FISH techniques for PGD.	—

Contacts

Public ContactKaren Sermon

Centre for Medical Genetics, UZ Brussel, Laarbeeklaan 101

karen.sermon@uzbrussel.be+32 2 477 60 73

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)