depression, mood disorders, depressie, stemmingsstoornis
Conditions
Interventions
This study will be a double-blind, placebo-controlled, cross-over study. Volunteers will be randomly assigned to one of two treatment sequences. Each volunteer will receive the dual action antidepress
Sponsors
Radboud University Nijmegen Medical Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1. Subjects must be at least 18 but not older than 50 years of age. 2. Subjects must have given a written informed consent. 3. They must have good physical and mental health as determined by medical history and medical, ECG and laboratory examination. 4. Their Body Mass Index between 18.5-24.9.
Exclusion criteria
Exclusion criteria: 1. Known hypersensitivity to duloxetine or any of the inactive ingredients. 2. Contra-indications for duloxetine (hepatic impairment, severe renal impairment with a GFR 170 mm Hg; diastolic > 100 mm Hg; 13. Participation in another drug study within 3 months preceding this study; 14. Orthostatic dysregulation at the screening examination; 15. Uncontrolled Narrow-Angle Glaucoma; 16. Post-menopausal women, pregnant women, lactating women and women without adequate hormonal anticonception; 17. Inability to understand the nature and extent of the trial and the procedures required; 18. Inability to understand the procedures of the neuropsycholoigcal tests; 19. Contraindication to MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main outcome-measures consist of behavioral measures as well as statistical maps of the functional imaging data as measured by fMRI. Three tests will be administered targetting: - perception of emotionally valenced pictures - the processing of punishment and reward monetary reward task - memory bias with regards to emotional valence. | — |
Secondary
| Measure | Time frame |
|---|---|
| Behavioral measures on: mood, anxiety, and hostility. | — |
Contacts
Public ContactRobbert J Verkes
Radboud University Nijmegen Medical Centre Department of Psychiatry, 966 PO Box 9101
Outcome results
None listed