Acute and chronic pain Pain relief Analgesia
Conditions
Interventions
Analgetic drug (alfentanil = 100ng/ml) infusion. Subjects will score thermal and electrical pain before and during alfentanil and placebo infusion (crossover design). We will assess whether the variab
Sponsors
LUMC
Eligibility
Inclusion criteria
Inclusion criteria: Volunteer inclusion criteria: 1. Healthy subjects of either sex between the age of 18 and 75; 2. Being able to give written informed consent. Patient inclusion criteria: 1. Patients diagnosed with fibromyalgia or peripheral polyneuropathy according to the guidelines of the IASP or other professional pain societies (e.g., Netherlands Society of Anesthesiologists); or patients scheduled for elective abdominal surgery with post-operative PCA or PCEA; 2. A pain score of 5 or higher for chronic pain patients; 3. Age between 18 and 75 years; 4. Being able to give written informed consent.
Exclusion criteria
Exclusion criteria: Patient and volunteer exclusion criteria: 1. Unable to give written informed consent; 2. Medical disease such as pulmonary, renal, liver, cardiac, gastro-intestinal, vascular disease; 3. Allergy to study medication; 4. Use of strong opioids; 5. Use of benzodiazepines; 6. History of illicit drug abuse or alcohol abuse; 7. History of psychosis; 8. Epilepsy; 9. Raised intracranial pressure; 10. Pregnancy and/or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain scores (NRS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Variability in pain scores (NRS). | — |
Contacts
Public ContactL.C.J. Oudejans
Afdeling anesthesiologie P5-46 Albinusdreef 2
Outcome results
None listed